Dr Hughes trained in medicine at Oxford University during which she intercalated a doctorate in macrophage physiology . After training in Haematology in London she was appointed to lecturer in haematology with a special interest in lysosomal storage disorders at the Royal Free Hospital through UCL and subsequently to Senior Lecturer and consultant in 2008. She has led a comprehensive clinical trials program for LSDs, in particular Fabry disease. Dr Hughes has an international reputation as a principal investigator having been awarded NIHR principal leading principal investigator awards in 2015 and 2016. She has developed a laboratory research program successfully supervising PHD, MD and MSC students to thesis submission and award with the laboratory producing contributions in the area of bone pathophysiology in Gaucher disease and has recently described for the first time the increased incidence of malignancy in that Fabry disease. She is an author of over 160 papers in the area of macrophage biology and lysosomal Storage Disorders.
Within the hospital she is Clinical Director of haematology, Oncology and Palliative care and lead cancer physician. She has lead a range of initiatives to improve cancer patient’s outcomes and experience and has designed, lead and initiated a teaching a new academic program for multidisciplinary training of health care professional in cancer.